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Progress of a cell through its reproductive cycle of DNA synthesis and division is governed by a complex network of biochemical reactions controlling the activities of both M-phase- and S-phase-promoting factors. Standard chemical kinetic theory provides a disciplined method for expressing the molecular biologists' diagrams and intuition in precise mathematical form, so that qualitative and quantitative implications of our 'working models' can be derived and compared with experiment.


Journal article


Trends Biochem Sci

Publication Date





89 - 96


Animals *Cell Cycle Cyclins DNA/biosynthesis *Homeostasis Kinetics Mitosis *Models, Biological Protein Kinases