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Complex assemblies of interacting proteins carry out most of the interesting jobs in a cell, such as metabolism, DNA synthesis, movement and information processing. These physiological properties play out as a subtle molecular dance, choreographed by underlying regulatory networks. To understand this dance, a new breed of theoretical molecular biologists reproduces these networks in computers and in the mathematical language of dynamical systems.


Journal article


Nat Rev Mol Cell Biol

Publication Date





908 - 916


CDC2 Protein Kinase/genetics/physiology Cell Cycle/genetics/physiology *Cell Physiological Phenomena Computer Simulation Macromolecular Substances *Models, Biological Mutation Phenotype Schizosaccharomyces/cytology/genetics/physiology Schizosaccharomyces pombe Proteins/genetics/physiology Systems Theory