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Complex assemblies of interacting proteins carry out most of the interesting jobs in a cell, such as metabolism, DNA synthesis, movement and information processing. These physiological properties play out as a subtle molecular dance, choreographed by underlying regulatory networks. To understand this dance, a new breed of theoretical molecular biologists reproduces these networks in computers and in the mathematical language of dynamical systems.

Type

Journal article

Journal

Nat Rev Mol Cell Biol

Publication Date

2001

Volume

2

Pages

908 - 916

Keywords

CDC2 Protein Kinase/genetics/physiology Cell Cycle/genetics/physiology *Cell Physiological Phenomena Computer Simulation Macromolecular Substances *Models, Biological Mutation Phenotype Schizosaccharomyces/cytology/genetics/physiology Schizosaccharomyces pombe Proteins/genetics/physiology Systems Theory