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The eukaryotic cell-division cycle is regulated by three modules that control G(1)/S, G(2)/M and meta/anaphase transitions. By using mathematical modelling, we show the dynamic characteristics of these individual modules and we also assemble them together into a comprehensive model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression.

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

2003

Volume

31

Pages

1526 - 1529

Keywords

*Cell Cycle Eukaryotic Cells *Models, Biological