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The molecular networks regulating basic physiological processes in a cell can be converted into mathematical equations (eg differential equations) and solved by a computer. The division cycle of eukaryotic cells is an important example of such a control system, and fission yeast is an excellent test organism for the computational modelling approach. The mathematical model is tested by simulating wild-type cells and many known cell cycle mutants. This paper describes an example where this approach is useful in understanding multiple rounds of DNA synthesis (endoreplication) in fission yeast cells that lack the main (B-type) mitotic cyclin, Cdc13. It is proposed that the key physiological variable driving progression through the cell cycle during balanced growth and division is the mass/DNA ratio, rather than the mass/nucleus ratio.

Type

Journal article

Journal

Brief Funct Genomic Proteomic

Publication Date

2004

Volume

2

Pages

298 - 307

Keywords

*Cell Cycle *Cell Cycle Proteins Cell Nucleus/metabolism Cyclin B/metabolism DNA/biosynthesis DNA Replication G1 Phase G2 Phase Mitosis Models, Biological Models, Theoretical Mutation Nuclear Proteins/metabolism Phosphorylation Protein-Tyrosine Kinases/metabolism Schizosaccharomyces/*physiology Schizosaccharomyces pombe Proteins Software Time Factors cdc25 Phosphatases/metabolism