Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Iminosugars have therapeutic potential against a range of diseases, due to their efficacy as glycosidase inhibitors. A major challenge in the development of iminosugar drugs lies in making a compound that is selective for the glycosidase associated with a given disease. We report the synthesis of ToP-DNJ, an antiviral iminosugar-tocopherol conjugate. Tocopherol was incorporated into the design of the iminosugar in order to direct the drug to the liver and immune cells, specific tissues of interest for antiviral therapy. ToP-DNJ inhibits ER α-glucosidase II at low micromolar concentrations and selectively accumulates in the liver in vivo. In cellular assays, the drug showed efficacy exclusively in immune cells of the myeloid lineage. Taken together, these data demonstrate that inclusion of a native metabolite into an iminosugar provides selectivity with respect to target enzyme, target cell, and target tissue.

Original publication

DOI

10.1021/acschembio.7b00870

Type

Journal article

Journal

ACS Chem Biol

Publication Date

19/01/2018

Volume

13

Pages

60 - 65

Keywords

1-Deoxynojirimycin, Administration, Oral, Animals, Antiviral Agents, Dengue Virus, Endoplasmic Reticulum, Glycoside Hydrolase Inhibitors, HL-60 Cells, Hepacivirus, Humans, Inhibitory Concentration 50, Liver, Male, Mice, Inbred BALB C, Rats, Tissue Distribution, Tocopherols, alpha-Glucosidases