Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Disinhibition, the inability to inhibit inappropriate behavior, is seen in frontal-temporal degeneration, Alzheimer's disease, and stroke. Behavioral disinhibition leads to social and emotional impairments, including impulsive behavior and disregard for social conventions. The authors investigated the effects of lesions on behavioral disinhibition measured by the Neuropsychiatric Inventory in 177 veterans with traumatic brain injuries. The authors performed voxel-based lesion-symptom mapping using MEDx. Damage in the frontal and temporal lobes, gyrus rectus, and insula was associated with greater behavioral disinhibition, providing further evidence of the frontal lobe's involvement in behavioral inhibition and suggesting that these regions are necessary to inhibit improper behavior.

Original publication

DOI

10.1176/appi.neuropsych.14060126

Type

Journal article

Journal

J Neuropsychiatry Clin Neurosci

Publication Date

2015

Volume

27

Pages

193 - 198

Keywords

Brain, Brain Injuries, Brain Mapping, Humans, Inhibition, Psychological, Intelligence Tests, Male, Middle Aged, Neuropsychological Tests, Radiography, Tomography Scanners, X-Ray Computed, Veterans