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The observation that human immunodeficiency virus type 1 (HIV-1) mutations conferring resistance to one reverse transcriptase (RT) inhibitor may suppress resistance to other RT inhibitors provides a rationale for treating HIV-1 with certain RT inhibitor combinations. We examined phenotypic and genotypic changes during culture of a multinucleoside (zidovudine, didanosine, zalcitibine, and stavudine)-resistant HIV-1 strain with and without additional RT inhibitors (nevirapine and lamivudine). The development of nevirapine or lamivudine resistance by the multinucleoside-resistant strain was not accompanied by a reduction in zidovudine or didanosine resistance.


Journal article


Antimicrob Agents Chemother

Publication Date





2887 - 2890


Antiviral Agents, Cell Line, Cells, Cultured, Didanosine, Drug Interactions, Drug Resistance, Microbial, Drug Resistance, Multiple, Genotype, HIV-1, Humans, Lamivudine, Mutation, Nevirapine, Pyridines, Reverse Transcriptase Inhibitors, Virus Replication, Zidovudine