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Intercellular adhesion is a complex phenomenon central to the development, structure and functioning of all multicellular organisms. Adhesion is mediated by distinct families of cell-adhesion molecules (CAMs), and recent studies have identified key characteristics of CAMs that influence their function. Affinity and kinetic analyses using a novel technique based on surface plasmon resonance have shown that CAM interactions that mediate transient cell adhesion may have surprisingly low affinities and extremely fast dissociation rate constants.

Type

Journal article

Journal

Trends Biochem Sci

Publication Date

09/1994

Volume

19

Pages

354 - 358

Keywords

Cell Adhesion, Cell Adhesion Molecules, Cell Communication, Protein Binding