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The mammalian nuclear envelope (NE) can develop complex dynamic membrane-bounded invaginations in response to both physiological and pathological stimuli. Since the formation of these nucleoplasmic reticulum (NR) structures can occur during interphase, without mitotic NE breakdown and reassembly, some other mechanism must drive their development. Here we consider models for deformation of the interphase NE, together with the evidence for their potential roles in NR formation.

Original publication

DOI

10.1080/19491034.2016.1252893

Type

Journal article

Journal

Nucleus

Publication Date

02/01/2017

Volume

8

Pages

34 - 45

Keywords

NE, NR, chromosome territories, cytoskeleton, gene expression, membrane curvature, nuclear envelope, nucleoplasmic reticulum, Animals, Biomechanical Phenomena, Humans, Interphase, Membrane Lipids, Membrane Proteins, Nuclear Envelope