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ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins. Here we present a proteomic approach for direct in vivo identification and quantification of ADPr sites on histones. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.

Original publication

DOI

10.1038/nchembio.2180

Type

Journal article

Journal

Nat Chem Biol

Publication Date

12/2016

Volume

12

Pages

998 - 1000

Keywords

Adenosine Diphosphate, Cell Line, Tumor, DNA Damage, Histones, Humans, Protein Processing, Post-Translational, Proteomics, Serine