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The role of CD8+ T-cells in the development of diabetes in the nonobese diabetic (NOD) mouse remains controversial. Although it is widely agreed that class II-restricted CD4+ T-cells are essential for the development of diabetes in the NOD model, some studies have suggested that CD8+ T-cells are not required for beta-cell destruction. To assess the contribution of CD8+ T-cells to diabetes, we have developed a class of NOD mouse that lacks expression of beta 2-microglobulin (NOD-B2mnull). NOD-B2mnull mice, which lack both class I expression and CD8+ T-cells in the periphery, not only failed to develop diabetes but were completely devoid of insulitis. These results demonstrate an essential role for CD8+ T-cells in the initiation of the autoimmune response to beta-cells in the NOD mouse.

Original publication

DOI

10.2337/diab.43.3.500

Type

Journal article

Journal

Diabetes

Publication Date

03/1994

Volume

43

Pages

500 - 504

Keywords

Animals, Autoimmune Diseases, Base Sequence, CD8 Antigens, Diabetes Mellitus, Type 1, Female, Islets of Langerhans, Mice, Mice, Inbred NOD, Molecular Sequence Data, Spleen, T-Lymphocytes, beta 2-Microglobulin