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This paper focuses on the relationship between the circadian system and glucose metabolism. Research across the translational spectrum confirms the importance of the circadian system for glucose metabolism and offers promising clues as to when and why these systems go awry. In particular, basic research has started to clarify the molecular and genetic mechanisms through which the circadian system regulates metabolism. The study of human behavior, especially in the context of psychiatric disorders, such as bipolar disorder and major depression, forces us to see how inextricably linked mental health and metabolic health are. We also emphasize the remarkable opportunities for advancing circadian science through big data and advanced analytics. Advances in circadian research have translated into environmental and pharmacological interventions with tremendous therapeutic potential.

Original publication




Journal article


Ann N Y Acad Sci

Publication Date





21 - 40


circadian rhythms, genetics, glucose, metabolism, mood disorders, Animals, Brain, Circadian Rhythm, Clinical Trials as Topic, Gastrointestinal Tract, Humans, Metabolic Diseases, Mood Disorders