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BACKGROUND: A permanent Parkinsonian syndrome occurs in intravenous abusers of the designer psychostimulant methcathinone (ephedrone). It is attributed to deposition of contaminant manganese, as reflected by characteristic globus pallidus hyperintensity on T1-weighted MRI. METHODS: We have investigated brain structure and function in methcathinone abusers (n = 12) compared to matched control subjects (n = 12) using T1-weighted structural and resting-state functional MRI. RESULTS: Segmentation analysis revealed significant (p 

Original publication




Journal article


Brain Behav

Publication Date





MRI, Parkinsonism, ephedrone, manganese toxicity, methcathinone, Adult, Atrophy, Brain, Case-Control Studies, Female, Gray Matter, Humans, Magnetic Resonance Imaging, Male, Manganese Poisoning, Parkinsonian Disorders, Propiophenones, Substance-Related Disorders, Young Adult