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Computational modelling, combined with experimental investigations, is a powerful method for investigating complex cardiac electrophysiological behaviour. The use of rabbit-specific models, due to the similarities of cardiac electrophysiology in this species with human, is especially prevalent. In this paper, we first briefly review rabbit-specific computational modelling of ventricular cell electrophysiology, multi-cellular simulations including cellular heterogeneity, and acute ischemia. This mini-review is followed by an original computational investigation of variability in the electrophysiological response of two experimentally-calibrated populations of rabbit-specific ventricular myocyte action potential models to acute ischemia. We performed a systematic exploration of the response of the model populations to varying degrees of ischemia and individual ischemic parameters, to investigate their individual and combined effects on action potential duration and refractoriness. This revealed complex interactions between model population variability and ischemic factors, which combined to enhance variability during ischemia. This represents an important step towards an improved understanding of the role that physiological variability may play in electrophysiological alterations during acute ischemia.

Original publication

DOI

10.1016/j.pbiomolbio.2016.06.003

Type

Journal article

Journal

Prog Biophys Mol Biol

Publication Date

07/2016

Volume

121

Pages

169 - 184

Keywords

Cardiac cell electrophysiology, Computational modelling, Ischemia, Populations of models, Rabbit, Variability, Action Potentials, Acute Disease, Adenosine Triphosphate, Animals, Electrophysiological Phenomena, Heart Ventricles, Humans, Models, Cardiovascular, Myocardial Ischemia, Potassium, Rabbits, Species Specificity