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The role of the influenza A virus panhandle structure formed from the 3'- and 5'-terminal nucleotides of virion RNA segments was studied in both an RNA polymerase binding assay and an in vitro transcription assay. Despite recent indications that promoter activity is simply a function of the 3'-terminal sequence of virion RNA, our results show that both 3'- and 5'-terminal sequences are involved in the initiation of transcription. We propose a new model for the initiation of transcription which has implications for the mechanisms by which influenza virus transcription, replication, and polyadenylation may be regulated in the infected cell.

Type

Journal article

Journal

J Virol

Publication Date

06/1994

Volume

68

Pages

4092 - 4096

Keywords

Animals, Base Sequence, DNA-Directed RNA Polymerases, Humans, Influenza A virus, Models, Genetic, Molecular Sequence Data, Mutagenesis, Site-Directed, Nucleic Acid Conformation, Promoter Regions, Genetic, RNA, Messenger, RNA, Viral, Transcription, Genetic