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This review considers some of the recent advances made in the understanding of the pathogenic proteins known to aggregate and be implicated in neurodegenerative dementing disorders. It concentrates on the two most obvious candidates for the role of toxic protein in Alzheimer's disease (AD)--beta-amyloid peptide and tau--but also considers other proteins in this disorder and in less common but equally devastating diseases.

Type

Journal article

Journal

J Neurol Neurosurg Psychiatry

Publication Date

02/2002

Volume

72

Pages

152 - 161

Keywords

Alzheimer Disease, Amyloid, Brain, Extracellular Space, Humans, Huntingtin Protein, Inclusion Bodies, Nerve Tissue Proteins, Neurodegenerative Diseases, Nuclear Proteins, Peptide Fragments, Prions, Proteins, Synucleins, tau Proteins