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This study investigated possible associations between selected polymorphisms in the serotonin receptor genes, 5-HT2A and 5-HT2C, with the presence of co-morbid depressive illness at baseline in a community based cohort of 158 patients with late onset patients with Alzheimer's disease (AD). An association was found between the presence of major depressive illness at baseline and both the 5-HT2A and 5-HT2C polymorphisms. Specifically, homozygous carriers of the 5-HT2A C102 allele were five times more likely to have major depressive illness than heterozygotes. In addition, homozygous or hemizygous carriers of the 5-HT2C Ser allele were 12 times more likely to have major depressive illness than homozygous or hemizygous carriers of the 5-HT2C Cys allele.

Original publication




Journal article


Am J Med Genet B Neuropsychiatr Genet

Publication Date





40 - 43


Age of Onset, Aged, Aged, 80 and over, Alzheimer Disease, Cohort Studies, Comorbidity, Depression, Female, Genotype, Heterozygote, Homozygote, Humans, Male, Odds Ratio, Polymorphism, Genetic, Receptor, Serotonin, 5-HT2A, Receptor, Serotonin, 5-HT2C, Receptors, Serotonin, 5-HT2