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p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies.

Original publication

DOI

10.1016/j.neulet.2007.03.026

Type

Journal article

Journal

Neurosci Lett

Publication Date

11/05/2007

Volume

418

Pages

34 - 37

Keywords

Aged, Alzheimer Disease, Blotting, Western, Cell Line, Tumor, Fluorescent Antibody Technique, Humans, Microscopy, Confocal, Phosphorylation, Temporal Lobe, Tumor Suppressor Protein p53, tau Proteins