Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.

Original publication

DOI

10.3233/JAD-131841

Type

Journal article

Journal

J Alzheimers Dis

Publication Date

2014

Volume

40

Pages

37 - 43

Keywords

Apolipoprotein E, hippocampal volume, magnetic resonance imaging, young healthy adolescents, Adolescent, Apolipoprotein E4, Apolipoproteins E, Cohort Studies, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male