Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes. Here we show that in Trypanosoma congolense this receptor is instead expressed in the epimastigote developmental stage that occurs in the tsetse fly, where it acts as a haemoglobin receptor. We also present the structure of the T. congolense receptor in complex with haemoglobin. This allows us to propose an evolutionary history for this receptor, charting the structural and cellular changes that took place as it adapted from a role in the insect to a new role in the mammalian host.

Original publication

DOI

10.7554/eLife.13044

Type

Journal article

Journal

Elife

Publication Date

15/04/2016

Volume

5

Keywords

brucei, congolense, evolution, evolutionary biology, genomics, haptoglobin-haemoglobin receptor, infectious disease, microbiology, trypanosome, Animals, Crystallography, X-Ray, Evolution, Molecular, Hemoglobins, Models, Molecular, Protein Conformation, Protozoan Proteins, Receptors, Cell Surface, Trypanosoma congolense, Tsetse Flies