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Surface glycoproteins direct cellular targeting, attachment, and membrane fusion of arenaviruses and are the primary target for neutralizing antibodies. Despite significant conservation of the glycoprotein architecture across the arenavirus family, there is considerable variation in the molecular recognition mechanisms used during host cell entry. We review recent progress in dissecting these infection events and describe how arenaviral glycoproteins can be targeted by small-molecule antivirals, the natural immune response, and immunoglobulin-based therapeutics. Arenaviral glycoprotein-mediated assembly and infection pathways present numerous opportunities and challenges for therapeutic intervention.

Original publication




Journal article


Curr Opin Virol

Publication Date





70 - 75


Animals, Antibodies, Neutralizing, Antibodies, Viral, Antiviral Agents, Arenaviridae Infections, Arenavirus, Humans, Membrane Fusion, Membrane Glycoproteins, Mice, Viral Envelope Proteins, Viral Vaccines, Virus Internalization