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Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and highlight directions for further investigation.

Original publication

DOI

10.1016/j.chom.2016.02.013

Type

Journal article

Journal

Cell Host Microbe

Publication Date

09/03/2016

Volume

19

Pages

304 - 310

Keywords

HIV-1, macrophage, pathogenesis, reservoir, Animals, HIV Infections, HIV-1, Humans, Macaca, Macrophages, Models, Biological, Simian Acquired Immunodeficiency Syndrome, Simian Immunodeficiency Virus