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Gastrointestinal infection can provoke substantial disturbance at both a local as well as at a systemic level and may evolve into a chronic disease state. Our growing knowledge of gut-pathogen interactions has been based to a large extent on the use of genetically tractable model hosts such as the fruit fly Drosophila melanogaster. In this review we will summarise the growing literature and critically address the advantages and disadvantages of using this model to extrapolate results from studying pathogen virulence and intestinal responses to humans.

Original publication

DOI

10.1016/j.dci.2016.01.016

Type

Journal article

Journal

Dev Comp Immunol

Publication Date

11/2016

Volume

64

Pages

3 - 10

Keywords

Drosophila, Gut, Host-pathogen interaction, Innate immunity, Model organism, Pathogens, Animals, Disease Models, Animal, Drosophila melanogaster, Genetic Engineering, Host-Pathogen Interactions, Humans, Immunity, Innate, Intestines, Virulence