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Diverse biological and developmental functions are mediated by signalling through the epidermal growth factor (EGF) receptor. In flies, many different mechanisms are used to control and restrict EGF-R signalling, including ligand processing, ligand variety (an inhibitor as well as activators), transcription and perhaps subcellular localization of the receptor. Since the components of EGF-R signalling have been well conserved, understanding these different modes of receptor regulation in flies should lead to general insights into the strategies of receptor activation.

Original publication

DOI

10.1016/S0962-8924(97)01143-4

Type

Journal article

Journal

Trends Cell Biol

Publication Date

11/1997

Volume

7

Pages

431 - 436