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Growth and patterning of the Drosophila wing disc depends on the coordinated expression of the key regulatory gene vestigial both in the Dorsal-Ventral (D/V) boundary cells and in the wing pouch. We propose that a short-range signal originating from the core of the D/V boundary cells is responsible for activating EGFR in a zone of organizing cells on the edges of the D/V boundary. Using loss-of-function mutations and ectopic expression studies, we show that EGFR signaling is essential for vestigial transcription in these cells and for making them competent to undergo subsequent vestigial-mediated proliferation within the wing pouch.


Journal article



Publication Date





975 - 985


Animals, Body Patterning, Drosophila, Drosophila Proteins, Nuclear Proteins, Proto-Oncogene Proteins, Receptor, Epidermal Growth Factor, Signal Transduction, Wings, Animal, Wnt1 Protein