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Chromosome silencing by Xist RNA occurs in two steps; localisation in cis within the nuclear matrix to form a domain that corresponds to the territory of the inactive X chromosome elect, and transduction of silencing signals from Xist RNA to the underlying chromatin. Key factors that mediate these processes have been identified in a series of recent studies that harnessed comprehensive proteomic or genetic screening strategies. In this review we discuss these findings in light of prior knowledge both of Xist-mediated silencing and known functions/properties of the novel factors.

Original publication




Journal article


Semin Cell Dev Biol

Publication Date





58 - 70


Chromatin, Epigenetic, Non-coding RNA, X chromosome inactivation, Xist, Animals, Heterogeneous-Nuclear Ribonucleoproteins, Humans, Models, Genetic, RNA, Long Noncoding, RNA-Binding Proteins, X Chromosome Inactivation