Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

©, Copyright Taylor & Francis. Interest in radiation damage to macromolecules during structural experiments has a long history dating back to 1962, when the first room-temperature study of the phenomenon was carried out on crystals of myoglobin [1], and this interest has not abated over the last few years, since there remains a need to understand both the parameters that affect radiation damage progression and also the artifacts produced by it. Although there is now a growing body of literature pertaining to this topic, clear and foolproof methods for experimenters to routinely minimize damage have yet to emerge. Additionally, radiation damage is also a concern and limiting problem in other methods used in structural biology, such as electron microscopy [2] and SAXS [3, 4]. However, the recently available free electron lasers (FELs) have presented the possibility and promise that samples will give “diffraction before destruction”; is this indeed the “cure” for the challenges of radiation damage?

Original publication

DOI

10.1080/08940886.2015.1101322

Type

Journal article

Journal

Synchrotron Radiation News

Publication Date

02/11/2015

Volume

28

Pages

15 - 19