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The oomycete pathogen Phytophthora infestans secretes cystatin-like effector proteins (EPICs) that inhibit secreted host proteases during infection. We recently found that the C14 protease is a relevant target of EPICs and that this protease is under diversifying selection in wild potato species with which P. infestans has coevolved. Here we generated a model of the EPIC-C14 complex based on cystatin-papain crystal structures and discovered three regions where variant residues in C14 might be the result of an arms race between enzyme and inhibitor at the plant-pathogen interface.


Journal article


Plant Signal Behav

Publication Date





109 - 112


Amino Acid Sequence, Host-Pathogen Interactions, Models, Biological, Models, Molecular, Molecular Sequence Data, Peptide Hydrolases, Phytophthora infestans, Plant Proteins, Protease Inhibitors, Protein Structure, Tertiary, Solanum tuberosum, Substrate Specificity