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The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome.

Original publication

DOI

10.3390/vaccines1040497

Type

Journal article

Journal

Vaccines (Basel)

Publication Date

28/10/2013

Volume

1

Pages

497 - 512

Keywords

HIV-1, envelope glycoproteins, neutralizing antibodies, trimer, vaccine