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BACKGROUND: Deep Brain Stimulation (DBS) is an effective treatment for several neurological and psychiatric disorders. In order to gain insights into the therapeutic mechanisms of DBS and to advance future therapies a better understanding of the effects of DBS on large-scale brain networks is required. NEW METHOD: In this paper, we describe an experimental protocol and analysis pipeline for simultaneously performing DBS and intracranial local field potential (LFP) recordings at a target brain region during concurrent magnetoencephalography (MEG) measurement. Firstly we describe a phantom setup that allowed us to precisely characterise the MEG artefacts that occurred during DBS at clinical settings. RESULTS: Using the phantom recordings we demonstrate that with MEG beamforming it is possible to recover oscillatory activity synchronised to a reference channel, despite the presence of high amplitude artefacts evoked by DBS. Finally, we highlight the applicability of these methods by illustrating in a single patient with Parkinson's disease (PD), that changes in cortical-subthalamic nucleus coupling can be induced by DBS. COMPARISON WITH EXISTING APPROACHES: To our knowledge this paper provides the first technical description of a recording and analysis pipeline for combining simultaneous cortical recordings using MEG, with intracranial LFP recordings of a target brain nucleus during DBS.

Original publication

DOI

10.1016/j.jneumeth.2015.11.029

Type

Journal article

Journal

J Neurosci Methods

Publication Date

01/03/2016

Volume

261

Pages

29 - 46

Keywords

Deep Brain Stimulation (DBS), Local Field Potential (LFP), Magnetoencephalography (MEG), Parkinson's disease, Adult, Artifacts, Brain, Cortical Synchronization, Deep Brain Stimulation, Humans, Implantable Neurostimulators, Magnetoencephalography, Male, Models, Neurological, Parkinson Disease, Phantoms, Imaging, Signal Processing, Computer-Assisted