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PURPOSE: To determine the test-retest reproducibility of neurochemical concentrations obtained with a highly optimized, short-echo, single-voxel proton MR spectroscopy (MRS) pulse sequence at 3T and 7T using state-of-the-art hardware. METHODS: A semi-LASER sequence (echo time = 26-28 ms) was used to acquire spectra from the posterior cingulate and cerebellum at 3T and 7T from six healthy volunteers who were scanned four times weekly on both scanners. Spectra were quantified with LCModel. RESULTS: More neurochemicals were quantified with mean Cramér-Rao lower bounds (CRLBs) ≤20% at 7T than at 3T despite comparable frequency-domain signal-to-noise ratio. Whereas CRLBs were lower at 7T (P 

Original publication




Journal article


Magn Reson Med

Publication Date





1083 - 1091


3 Tesla, 7 Tesla, coefficient of variation, spectroscopy, test-retest reproducibility, Adult, Algorithms, Brain, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Molecular Imaging, Reproducibility of Results, Sensitivity and Specificity, Tissue Distribution