Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Total intracranial volume is a useful measure of inter-subject variability in pre-morbid brain volume, which has been recommended for inclusion in region of interest and voxel-based morphometric studies of dementia [1]. TIV can be estimated from structural MRI using time-consuming manual tracing or using automated methods. We show that recent improvements to the Statistical Parametric Mapping (SPM) software's unified segmentation method allow highly accurate and unbiased estimates to be obtained rapidly and without interaction.



Publication Date



total intracranial volume, TIV, ICV, SPM, VBM