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Polycomb group proteins are transcriptional repressors that are essential for normal gene regulation during development. Recent studies suggest that Polycomb repressive complexes (PRCs) recognize and are recruited to their genomic target sites through a range of different mechanisms, which involve transcription factors, CpG island elements and non-coding RNAs. Together with the realization that the interplay between PRC1 and PRC2 is more intricate than was previously appreciated, this has increased our understanding of the vertebrate Polycomb system at the molecular level.

Original publication




Journal article


Nat Rev Mol Cell Biol

Publication Date





643 - 649


Animals, Cell Cycle Proteins, Chromatin, CpG Islands, DNA-Binding Proteins, Gene Expression Regulation, Histones, Humans, Mice, Polycomb Repressive Complex 1, Polycomb Repressive Complex 2, RNA, Untranslated, RNA-Binding Proteins, Transcription Factors, Transcription, Genetic