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Recent findings from our and other laboratories indicate that cell cycle-related phenomena may play a key role in the formation of Alzheimer-type pathology and neuronal cell death in both Alzheimer's and cerebro-vascular diseases. In this study we examine the expression patterns of cyclins A, B1, D1 and E in neuronal nuclei in the hippocampus in autopsied healthy elderly individuals, Alzheimer's disease patients and subjects suffering from cerebrovascular disease with and without co-existing Alzheimer's disease. Nuclear cyclin B1 and cyclin E expression was detected in hippocampal neurones in each subject category. However, cyclin B1 expression was significantly elevated in the CA1 of patients suffering from cerebro-vascular disease alone, while cyclin E expression was significantly higher in the CA4 subfield in patients suffering from mixed Alzheimer's and cerebro-vascular diseases compared to subjects in other categories. We hypothesize that cell cycle re-entry may occur in healthy elderly people leading to age-related cell death and mild Alzheimer-type pathology in the hippocampus. However, in pathological conditions, the cell cycle arrest may lead either to the development of severe Alzheimer-related pathology or to excess apoptotic cell death as in vascular dementia.

Original publication

DOI

10.1016/s0304-3940(99)00509-1

Type

Journal article

Journal

Neurosci Lett

Publication Date

13/08/1999

Volume

271

Pages

45 - 48

Keywords

Aged, Aged, 80 and over, Alzheimer Disease, Autopsy, Cell Cycle, Cell Nucleus, Cerebrovascular Disorders, Cyclin A, Cyclin B, Cyclin B1, Cyclin D1, Cyclin E, Cyclins, Dementia, Vascular, Hippocampus, Humans, Neurons, Reference Values