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There is extensive transcription throughout the eukaryotic genome resulting in both antisense transcripts from coding regions and cryptic unstable transcripts (CUTs) from intergenic regions. In this issue, Camblong et al. (2007) demonstrate in the budding yeast that antisense transcripts, if stabilized by exosome impairment, are able to mediate gene silencing via the recruitment of histone deacetylases.

Original publication

DOI

10.1016/j.cell.2007.11.003

Type

Journal article

Journal

Cell

Publication Date

16/11/2007

Volume

131

Pages

649 - 651

Keywords

Animals, Gene Expression Regulation, Fungal, Gene Silencing, Histone Deacetylases, RNA, Antisense, RNA, Fungal, Saccharomyces cerevisiae, Transcription, Genetic