Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Many different pathways contribute to the maintenance of tolerance to harmless antigens in the intestine. When these important pathways are compromised, chronic intestinal inflammation can develop. In particular, naturally occurring CD4+CD25+ regulatory T cells have been shown to play an important role in the prevention and cure of colitis in animal models of intestinal inflammation. These regulatory T cell responses may be influenced by the local environment in the intestine. For example, functionally specialised populations of dendritic cells exist in the intestine which may favour regulatory type responses. Understanding how these pathways intersect may lead to the development of more specific therapies for the treatment of inflammatory bowel disease.

Original publication




Journal article


Semin Immunol

Publication Date





116 - 126


Bacteria, Bacterial Physiological Phenomena, Cytokines, Dendritic Cells, Homeostasis, Humans, Immune Tolerance, Immunity, Mucosal, Inflammatory Bowel Diseases, Intestinal Mucosa, Lymphocyte Activation, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory