Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

© The editors and contributors, 1996. All rights reserved. The precise mechanism by which vascular tone is coupled to regional neuronal metabolism is not known, but it is likely to be multifactorial, reflecting the concerted action of changes in the local ionic composition of the extracellular fluid (K < sup > + < /sup > , H < sup > + < /sup > , pC0 < inf > 2 < /inf > , and pO < inf > 2 < /inf > ) and changes in the concentration of chemical transmitters and neuromodulators released from the neurones of the brain. Superimposed upon these controlling processes is the influence of perivascular nerves, which appears to predominate in larger cerebral arteries, factors released from intimal endothelial cells, and the passive myogenic properties of cerebrovascular smooth muscle cells. The complex nature of the link between cerebral blood flow and metabolism, and the possible mediation of neurotransmitters, necessitates in vitro pharmacological studies, where the kinetics of agonist/receptor interactions can be examined under controlled, steady state conditions.

Original publication

DOI

10.1093/acprof:oso/9780192623874.003.0011

Type

Chapter

Book title

The Pharmacology of Vascular Smooth Muscle

Publication Date

22/03/2012