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Recent studies have questioned the idea that the Golgi complex is a stable organelle with a unique identity through which secretory cargo is transported by vesicles. Instead, it is proposed that Golgi apparatus proteins continuously recycle via the endoplasmic reticulum by vesicle transport, whereas cargo molecules remain in maturing cisternal structures. Rather than forming a rigid matrix, structural Golgi proteins might be highly dynamic and recycle via the cytoplasm. I will discuss the evidence for these claims and consider whether or not they really disprove older ideas on how the Golgi apparatus is structured and performs its function.

Type

Journal article

Journal

Trends Cell Biol

Publication Date

03/2002

Volume

12

Pages

101 - 104

Keywords

Animals, COP-Coated Vesicles, Carrier Proteins, Endoplasmic Reticulum, Golgi Apparatus, Humans, Protein Transport