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One of the characteristics of the mammalian Golgi is its position adjacent to the nucleus. This characteristic is maintained through the action of the microtubule (MT) minus end-directed motor dynein and MT-associated proteins (MAPs). Recent findings suggest that GMAP-210, a member of the golgin family of proteins, may help to link Golgi membranes and vesicles with the MT cytoskeleton. However, there are good grounds to doubt that either GMAP-210 or its yeast homologue Rud3p is a MAP. Instead, they appear to function in vesicle trafficking events at the Golgi together with the GTPase ARF1 and a small membrane protein, Erv14. As such, the interesting question of how the Golgi interacts with MTs may well remain open to further investigation.

Original publication

DOI

10.1083/jcb.200501088

Type

Journal article

Journal

J Cell Biol

Publication Date

28/03/2005

Volume

168

Pages

993 - 998

Keywords

ADP-Ribosylation Factor 1, Animals, Golgi Apparatus, Humans, Intracellular Membranes, Membrane Proteins, Microtubule-Associated Proteins, Microtubules, Nuclear Proteins, Protein Transport, Saccharomyces cerevisiae Proteins, Transport Vesicles