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In this review we will focus on the recent advances in how coiled-coil proteins of the golgin family give identity and structure to the Golgi apparatus in animal cells. A number of recent studies reveal a common theme for the targeting of golgins containing the ARL-binding GRIP domain, and the related ARF-binding GRAB domain. Similarly, other golgins such as the vesicle tethering factor p115 and Bicaudal-D are targeted by the Rab GTPases, Rab1 and Rab6, respectively. Together golgins and their regulatory GTPases form a complex network, commonly known as the Golgi matrix, which organizes Golgi membranes and regulates membrane trafficking.

Original publication

DOI

10.1016/j.bbamcr.2005.02.001

Type

Journal article

Journal

Biochim Biophys Acta

Publication Date

10/07/2005

Volume

1744

Pages

383 - 395

Keywords

Animals, Apoptosis, Cytoskeleton, Golgi Apparatus, Membrane Proteins, Mitosis, rab GTP-Binding Proteins