Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

In this article, we consider the functions of the myotubularins - a large family of phosphoinositide 3-phosphatases. By analogy with the phosphatidylinositol 3-phosphatase PTEN (phosphatase and tensin homolog deleted in chromosome ten) and many protein phosphatases, it has been proposed that the primary function of this protein family is to regulate substrate levels, in this case phosphatidylinositol (3)-phosphate. We propose an alternate, or additional, function that is analogous to the G-protein family of phosphatases, which use nucleotide-dependent conformational changes to transduce signals or do mechanical work.

Original publication

DOI

10.1016/j.tibs.2003.12.005

Type

Journal article

Journal

Trends Biochem Sci

Publication Date

02/2004

Volume

29

Pages

58 - 61

Keywords

Endocytosis, Enzyme Activation, Feedback, Physiological, Models, Biological, Mutation, Phosphatidylinositol Phosphates, Phosphoric Monoester Hydrolases, Protein Conformation, Protein Structure, Tertiary, Protein Tyrosine Phosphatases, Protein Tyrosine Phosphatases, Non-Receptor, Signal Transduction, Substrate Specificity, Tumor Suppressor Proteins