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Developmental regulation of the mouse Xist gene at the onset of X chromosome inactivation is mediated by RNA stabilization. Here, we show that alternate promoter usage gives rise to distinct stable and unstable RNA isoforms. Unstable Xist transcript initiates at a novel upstream promoter, whereas stable Xist RNA is transcribed from the previously identified promoter and from a novel downstream promoter. Analysis of cells undergoing X inactivation indicates that a developmentally regulated promoter switch mediates stabilization and accumulation of Xist RNA on the inactive X chromosome.


Journal article



Publication Date





809 - 817


Animals, Cell Line, Dosage Compensation, Genetic, Embryonic and Fetal Development, Gene Expression Regulation, Developmental, In Situ Hybridization, Fluorescence, Mice, Mice, Transgenic, Molecular Sequence Data, Promoter Regions, Genetic, RNA, Long Noncoding, RNA, Messenger, RNA, Untranslated, Transcription Factors, Transcription, Genetic, X Chromosome