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Perfluorohexane gas when introduced in the air atmosphere above a film of phospholipid self-supported on an aqueous solution of C2F5-labeled compounds causes the recruitment and immobilization of the latter in the interfacial film. When the phospholipid forms a liquid-condensed Gibbs monolayer, which is the case for dipalmitoylphosphatidylcholine (DPPC), the C2F5-labeled molecule remains trapped in the monolayer after removal of F-hexane. Investigations involve bubble profile analysis tensiometry (Gibbs films), Langmuir monolayers and microbubble experiments. The new phenomenon was utilized to incorporate a hypoxia biomarker, a C2F5-labeled nitrosoimidazole (EF5), in microbubble shells. This finding opens perspectives in the delivery of fluorinated therapeutic molecules and biomarkers.

Original publication




Journal article


Angew Chem Int Ed Engl

Publication Date





8402 - 8406


drug delivery, fluorocarbons, microbubbles, molecular recognition, phospholipid interfaces, 1,2-Dipalmitoylphosphatidylcholine, Drug Delivery Systems, Fluorocarbons, Gases, Hydrocarbons, Fluorinated, Imidazoles, Microbubbles, Nitroso Compounds