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BACKGROUND: Anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies directed against the GluN1 subunit are considered highly specific for anti-N-methyl-D-aspartate receptor encephalitis, a severe clinical syndrome characterized by seizures, psychiatric symptoms, orofacial dyskinesia and autonomic dysfunction. CASE PRESENTATION: Here we report a 33 year old Caucasian male patient with clinically definite multiple sclerosis who was found to be positive for anti-N-methyl-D-aspartate receptor antibodies. Rituximab therapy was initiated. On the 18 months follow-up visit the patient was found to be clinically stable, without typical signs of anti-N-methyl-D-aspartate receptor encephalitis. CONCLUSION: Our findings add to the growing evidence for a possible association between anti-N-methyl-D-aspartate receptor encephalitis and demyelinating diseases.

Original publication

DOI

10.1186/1756-0500-7-948

Type

Journal article

Journal

BMC Res Notes

Publication Date

23/12/2014

Volume

7

Keywords

Adult, Antibodies, Monoclonal, Murine-Derived, Autoantibodies, Demyelinating Autoimmune Diseases, CNS, Humans, Immunoglobulin G, Immunologic Factors, Male, Multiple Sclerosis, Receptors, N-Methyl-D-Aspartate, Rituximab, Treatment Outcome