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No thymomatous myasthenia gravis (TMG) has been reported in patients with anti-α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor encephalitis (AMPAR-E). We described clinical presentation and autoimmune profile of the first case with both AMPAR-E and TMG. Clinical information was obtained from original medical records. Antibodies against AMPAR and confounding antigens were examined on transfected human embryonic kidney 293 cells by the indirect immunofluorescence method. In this case, anti-AMPAR antibodies and anti-acetylcholine receptor (AchR) antibodies were both positive and could explain the encephalitis and MG respectively. This report also indicated the complexity of autoimmunity network associated with thymoma. However, the relationships between thymoma, MG and AMPAR-E remained unclear.

Original publication

DOI

10.1016/j.jneuroim.2015.02.011

Type

Journal article

Journal

J Neuroimmunol

Publication Date

15/04/2015

Volume

281

Pages

35 - 37

Keywords

AMPA receptors, Autoimmune encephalitis, Myasthenia, Thymoma, Autoantibodies, Encephalitis, Female, HEK293 Cells, Humans, Middle Aged, Myasthenia Gravis, Receptors, AMPA, Thymoma, Thymus Neoplasms