Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Introduction Conventional diffusion MRI provides exquisite sensitivity to tissue microstructure through models of restricted and hindered diffusion within and around axons, respectively. These models often idealize axons as parallel, infinite and impermeable cylinders, where diffusion is often assumed to be free along the direction of axons. However, quantification of the degree of diffusion hindrance parallel to axon bundles, or the permeability of axon walls, may be possible with measurements at a range of diffusion times longer than those in typical experiments. At longer diffusion times, spins have an opportunity to probe longer length/time scales. Here, we present long diffusion time measurements of in vivo white matter using stimulated echoes and compare the fitting quality of successively simpler models of the diffusion attenuation accounting for overfitting.

Type

Conference paper

Publication Date

2015

Pages

792 - 792

Addresses

Toronto, Canada