Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The 164 bp U1 small nuclear (sn) RNA is one of the most abundant noncoding (nc) RNA in human cells, estimated to be in the region of 10(6) copies/cell. Although best known for its role in pre-messenger RNA (mRNA) splicing events, research over the past 20 years has revealed diverse functions of this ncRNA in mammalian cell types. Excellent reviews exist detailing the role of U1 snRNA in pre-mRNA splicing events. This review highlights what is currently known regarding the additional roles, snRNP composition, expression profiles, and the genomic organization of this ncRNA.

Original publication

DOI

10.1002/wrna.1257

Type

Journal article

Journal

Wiley Interdiscip Rev RNA

Publication Date

01/2015

Volume

6

Pages

79 - 92

Keywords

Animals, Gene Expression Regulation, Humans, Mammals, RNA Precursors, RNA Processing, Post-Transcriptional, Ribonucleoprotein, U1 Small Nuclear