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The purpose of this study was to test whether an empirical mathematical model (EMM) of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can distinguish between benign and malignant breast lesions. A modified clinical protocol was used to improve the sampling of contrast medium uptake and washout. T(1)-weighted DCE magnetic resonance images were acquired at 1.5 T for 22 patients before and after injection of Gd-DTPA. Contrast medium concentration as a function of time was calculated over a small region of interest containing the most rapidly enhancing pixels. Then the curves were fitted with the EMM, which accurately described contrast agent uptake and washout. Results demonstrate that benign lesions had uptake (P<2.0 x 10(-5)) and washout (P

Original publication




Journal article


Magn Reson Imaging

Publication Date





593 - 603


Adult, Aged, Breast Neoplasms, Contrast Media, Diagnosis, Differential, Female, Gadolinium DTPA, Humans, Magnetic Resonance Imaging, Middle Aged, Models, Theoretical, Sensitivity and Specificity