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The purpose of this research was to test whether dynamic contrast enhanced MRI could assess the effect of green tea on the angiogenic properties of transplanted rodent tumors. Copenhagen rats bearing AT6.1 prostate tumors inoculated in the hind limbs were randomly assigned to cages in which they were allowed to only drink either plain water (control group) or water containing green tea extract (treated group). Assignments were made after a baseline MRI experiment (week 0) was performed on each rat at 4.7T. All the rats were subsequently imaged at day 7 (week 1) and day 14 (week 2) to follow tumor growth and vascular development. The two-compartment pharmacokinetic model was used to analyze the dynamic contrast Gd-DTPA enhanced MRI data on a pixel-by-pixel basis over the tumor area to obtain the volume transfer constant (K(trans)) and extravascular extracellular space (v(e)). An identity Chi-squared test showed that the distributions of averaged histograms (n=6) of K(trans) and v(e) were significantly different from week 0 to both weeks 1 and 2 (p<0.001) in both the control and the treated rats due to increasing areas of tumor necrosis. However, the tumor growth rate was statistically indistinguishable between control and treated rats. There was no significant difference in the distributions of K(trans) and v(e) between control and treated rats. The results showed that no effects of green tea on tumor micro-vasculature were measurable by dynamic Gd-DTPA enhanced MRI.

Original publication

DOI

10.1016/j.ejmp.2009.07.001

Type

Journal article

Journal

Phys Med

Publication Date

04/2010

Volume

26

Pages

111 - 116

Keywords

Angiogenesis Modulating Agents, Animals, Camellia sinensis, Contrast Media, Extracellular Space, Gadolinium DTPA, Magnetic Resonance Imaging, Male, Microvessels, Models, Biological, Neoplasm Transplantation, Neovascularization, Pathologic, Plant Extracts, Prostatic Neoplasms, Rats, Time Factors