Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The efficiency of interaction of helper T cells with memory B cells of varying histocompatibility types has been studied in an in vitro microculture system. Such studies show that I-A region matching does not necessarily determine that efficient co-operation will take place. Failure to co-operate under circumstances where T and B cells match in I-A can be attributed to radiosensitive suppressor T cells. The nature of the gene differences which provoke the activity of such suppressor cells have also been examined, and it would seem that even single S.D. differences in the MHC are sufficient to generate 'suppressor' T-cell activity.

Type

Journal article

Journal

Immunology

Publication Date

07/1977

Volume

33

Pages

129 - 139

Keywords

Animals, Antibody-Producing Cells, B-Lymphocytes, Cells, Cultured, Genes, Histocompatibility, Immunologic Memory, Immunosuppression, Mice, T-Lymphocytes